3KRW

Human GRK2 in complex with Gbetgamma subunits and balanol (soak)

3KRW の概要

• エントリーDOI: 10.2210/pdb3krw/pdb
• 関連するPDBエントリー: 1BX6 1OMW 3CIK 3KRX
• 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: protein kinase, inhibitor, complex, wd40, ph domain, rgs homology domain, atp-binding, kinase, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, acetylation, transducer, wd repeat, cell membrane, lipoprotein, membrane, methylation, prenylation, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 125959.85

構造登録者

Tesmer, J.J.G.,Tesmer, V.M. (登録日: 2009-11-19, 公開日: 2010-02-16, 最終更新日: 2023-09-06)

• 主引用文献: Tesmer, J.J.,Tesmer, V.M.,Lodowski, D.T.,Steinhagen, H.,Huber, J.; Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.; J.Med.Chem., 53:1867-1870, 2010; PubMed: 20128603; DOI: 10.1021/jm9017515

実験手法

X-RAY DIFFRACTION (2.9 Å)