3KRD

Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with Fellutamide B

3KRD の概要

• エントリーDOI: 10.2210/pdb3krd/pdb
• 関連するPDBエントリー: 2FHG 2FHH 3H6F 3H6I 3HF9 3HFA
• 分子名称: Proteasome subunit alpha, Proteasome subunit beta, Fellutamide B, ... (5 entities in total)
• 機能のキーワード: binding sites, mycobacterium tuberculosis, protein subunits, substrate specificity, hydrolase, proteasome, fellutamide b, inhibition, protease, threonine protease, virulence, autocatalytic cleavage, zymogen
• 由来する生物種: Mycobacterium tuberculosis; 詳細
• 細胞内の位置: Cytoplasm (By similarity): A5U4D5 A5U4D6
• タンパク質・核酸の鎖数: 42
• 化学式量合計: 738850.35

構造登録者

Li, D.,Li, H. (登録日: 2009-11-18, 公開日: 2010-09-29, 最終更新日: 2024-03-27)

• 主引用文献: Lin, G.,Li, D.,Chidawanyika, T.,Nathan, C.,Li, H.; Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.; Arch.Biochem.Biophys., 501:214-220, 2010; PubMed: 20558127; DOI: 10.1016/j.abb.2010.06.009

実験手法

X-RAY DIFFRACTION (2.5 Å)