3KNT

Crystal structure of Methanocaldococcus jannaschii 8-oxoguanine glycosylase/lyase in complex with 15mer DNA containing 8-oxoguanine

Summary for 3KNT

• Entry DOI: 10.2210/pdb3knt/pdb
• Descriptor: N-glycosylase/DNA lyase, 5'-D(*AP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*TP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', ... (5 entities in total)
• Functional Keywords: protein-dna complex, ogg, helix-hairpin-helix, glycosylase, 8-oxoguanine, 8-oxog, dna repair, dna damage, glycosidase, multifunctional enzyme, nuclease, hydrolase, lyase-dna complex, lyase/dna
• Biological source: Methanocaldococcus jannaschii (Methanococcus jannaschii); More
• Total number of polymer chains: 12
• Total formula weight: 136351.04

Authors

Faucher, F.,Doublie, S. (deposition date: 2009-11-12, release date: 2010-02-02, Last modification date: 2023-09-06)

• Primary citation: Faucher, F.,Wallace, S.S.,Doublie, S.; The C-terminal Lysine of Ogg2 DNA Glycosylases is a Major Molecular Determinant for Guanine/8-Oxoguanine Distinction.; J.Mol.Biol., 397:46-56, 2010; PubMed: 20083120; DOI: 10.1016/j.jmb.2010.01.024

Experimental method

X-RAY DIFFRACTION (2.7 Å)