3KNT

Crystal structure of Methanocaldococcus jannaschii 8-oxoguanine glycosylase/lyase in complex with 15mer DNA containing 8-oxoguanine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0016829	molecular_function	lyase activity
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0003824	molecular_function	catalytic activity
B	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
B	0016829	molecular_function	lyase activity
B	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C	0003824	molecular_function	catalytic activity
C	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
C	0016829	molecular_function	lyase activity
C	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D	0003824	molecular_function	catalytic activity
D	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
D	0016829	molecular_function	lyase activity
D	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 208

Chain	Residue
A	VAL120
A	ILE123
A	ILE126
E	DC26

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 208

Chain	Residue
B	VAL120
B	ILE123
B	ILE126
G	DC26

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA C 208

Chain	Residue
C	ILE123
C	ILE126
I	DC26
C	VAL120

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA D 208

Chain	Residue
D	VAL120
D	ILE123
D	ILE126
K	DC26

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00241, ECO:0000305|PubMed:19446526

Chain	Residue	Details
A	GLN129
A	ASP147
B	GLN129
B	ASP147
C	GLN129
C	ASP147
D	GLN129
D	ASP147

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Important for guanine/8-oxoguanine distinction => ECO:0000255|HAMAP-Rule:MF_00241, ECO:0000269|PubMed:19446526, ECO:0000269|PubMed:20083120

Chain	Residue	Details
A	LYS207
B	LYS207
C	LYS207
D	LYS207

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