3KNT

Crystal structure of Methanocaldococcus jannaschii 8-oxoguanine glycosylase/lyase in complex with 15mer DNA containing 8-oxoguanine

3KNT の概要

• エントリーDOI: 10.2210/pdb3knt/pdb
• 分子名称: N-glycosylase/DNA lyase, 5'-D(*AP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*TP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', ... (5 entities in total)
• 機能のキーワード: protein-dna complex, ogg, helix-hairpin-helix, glycosylase, 8-oxoguanine, 8-oxog, dna repair, dna damage, glycosidase, multifunctional enzyme, nuclease, hydrolase, lyase-dna complex, lyase/dna
• 由来する生物種: Methanocaldococcus jannaschii (Methanococcus jannaschii); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 136351.04

構造登録者

Faucher, F.,Doublie, S. (登録日: 2009-11-12, 公開日: 2010-02-02, 最終更新日: 2023-09-06)

• 主引用文献: Faucher, F.,Wallace, S.S.,Doublie, S.; The C-terminal Lysine of Ogg2 DNA Glycosylases is a Major Molecular Determinant for Guanine/8-Oxoguanine Distinction.; J.Mol.Biol., 397:46-56, 2010; PubMed: 20083120; DOI: 10.1016/j.jmb.2010.01.024

実験手法

X-RAY DIFFRACTION (2.7 Å)