3KMZ

Crystal structure of RARalpha ligand binding domain in complex with the inverse agonist BMS493 and a corepressor fragment

Summary for 3KMZ

Entry DOI	10.2210/pdb3kmz/pdb
Descriptor	Retinoic acid receptor alpha, Nuclear receptor corepressor 1, 4-{(E)-2-[5,5-dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl]ethenyl}benzoic acid, ... (5 entities in total)
Functional Keywords	nuclear receptor transcription factor ligand binding domain, dna-binding, metal-binding, nucleus, phosphoprotein, proto-oncogene, receptor, transcription, transcription regulation, zinc-finger, chromatin regulator, repressor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P10276 Nucleus (By similarity): O75376
Total number of polymer chains	4
Total formula weight	66066.24
Authors	Bourguet, W.,le Maire, A. (deposition date: 2009-11-11, release date: 2010-06-02, Last modification date: 2023-11-22)
Primary citation	le Maire, A.,Teyssier, C.,Erb, C.,Grimaldi, M.,Alvarez, S.,de Lera, A.R.,Balaguer, P.,Gronemeyer, H.,Royer, C.A.,Germain, P.,Bourguet, W. A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor. Nat.Struct.Mol.Biol., 17:801-807, 2010 Cited by PubMed: 20543827 DOI: 10.1038/nsmb.1855 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation