3KMZ
Crystal structure of RARalpha ligand binding domain in complex with the inverse agonist BMS493 and a corepressor fragment
Summary for 3KMZ
Entry DOI | 10.2210/pdb3kmz/pdb |
Descriptor | Retinoic acid receptor alpha, Nuclear receptor corepressor 1, 4-{(E)-2-[5,5-dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl]ethenyl}benzoic acid, ... (5 entities in total) |
Functional Keywords | nuclear receptor transcription factor ligand binding domain, dna-binding, metal-binding, nucleus, phosphoprotein, proto-oncogene, receptor, transcription, transcription regulation, zinc-finger, chromatin regulator, repressor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P10276 Nucleus (By similarity): O75376 |
Total number of polymer chains | 4 |
Total formula weight | 66066.24 |
Authors | Bourguet, W.,le Maire, A. (deposition date: 2009-11-11, release date: 2010-06-02, Last modification date: 2023-11-22) |
Primary citation | le Maire, A.,Teyssier, C.,Erb, C.,Grimaldi, M.,Alvarez, S.,de Lera, A.R.,Balaguer, P.,Gronemeyer, H.,Royer, C.A.,Germain, P.,Bourguet, W. A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor. Nat.Struct.Mol.Biol., 17:801-807, 2010 Cited by PubMed: 20543827DOI: 10.1038/nsmb.1855 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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