3KMG

The X-ray Crystal Structure of PPAR-gamma in Complex with an Indole Derivative Modulator, GSK538, and an SRC-1 Peptide

3KMG の概要

• エントリーDOI: 10.2210/pdb3kmg/pdb
• 関連するPDBエントリー: 1fm6 1fm9 1prg 2prg
• 分子名称: Peroxisome proliferator-activated receptor gamma, Steroid Receptor Coactivator-1, 4'-[(2,3-dimethyl-5-{[(1S)-1-phenylpropyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: ppar-gamma, peroxisome proliferator-activated receptor, telmisartan, diabetes, modulator, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 68881.94

構造登録者

Gampe, R. (登録日: 2009-11-10, 公開日: 2010-01-12, 最終更新日: 2024-10-30)

• 主引用文献: Lamotte, Y.,Martres, P.,Faucher, N.,Laroze, A.,Grillot, D.,Ancellin, N.,Saintillan, Y.,Beneton, V.,Gampe, R.; Synthesis and biological activities of novel indole derivatives as potent and selective PPAR-gamma modulators; TO BE PUBLISHED,

実験手法

X-RAY DIFFRACTION (2.1 Å)