3KMG
The X-ray Crystal Structure of PPAR-gamma in Complex with an Indole Derivative Modulator, GSK538, and an SRC-1 Peptide
3KMG の概要
エントリーDOI | 10.2210/pdb3kmg/pdb |
関連するPDBエントリー | 1fm6 1fm9 1prg 2prg |
分子名称 | Peroxisome proliferator-activated receptor gamma, Steroid Receptor Coactivator-1, 4'-[(2,3-dimethyl-5-{[(1S)-1-phenylpropyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid, ... (4 entities in total) |
機能のキーワード | ppar-gamma, peroxisome proliferator-activated receptor, telmisartan, diabetes, modulator, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Nucleus: P37231 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 68881.94 |
構造登録者 | |
主引用文献 | Lamotte, Y.,Martres, P.,Faucher, N.,Laroze, A.,Grillot, D.,Ancellin, N.,Saintillan, Y.,Beneton, V.,Gampe, R. Synthesis and biological activities of novel indole derivatives as potent and selective PPAR-gamma modulators TO BE PUBLISHED, |
実験手法 | X-RAY DIFFRACTION (2.1 Å) |
構造検証レポート
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