3KHM
Crystal structure of sterol 14alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with inhibitor fluconazole
Summary for 3KHM
Entry DOI | 10.2210/pdb3khm/pdb |
Related | 3K1O |
Descriptor | Sterol 14 alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL (3 entities in total) |
Functional Keywords | sterol 14-alpha demethylase, cyp51, cytochrome p450, heme, oxidoreductase, monooxygenase, endoplasmic reticulum, transmembrane protein, sterol biosynthesis, lipids, membrane, iron, heme thiolate protein |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 1 |
Total formula weight | 53848.10 |
Authors | Lepesheva, G.I.,Hargrove, T.Y.,Anderson, S.,Wawrzak, Z.,Waterman, M.R. (deposition date: 2009-10-30, release date: 2009-11-10, Last modification date: 2023-09-06) |
Primary citation | Lepesheva, G.I.,Hargrove, T.Y.,Anderson, S.,Kleshchenko, Y.,Furtak, V.,Wawrzak, Z.,Villalta, F.,Waterman, M.R. Structural Insights into Inhibition of Sterol 14{alpha}-Demethylase in the Human Pathogen Trypanosoma cruzi. J.Biol.Chem., 285:25582-25590, 2010 Cited by PubMed: 20530488DOI: 10.1074/jbc.M110.133215 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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