3KE1
Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei in complex with a fragment-nucleoside fusion D000161829
Summary for 3KE1
Entry DOI | 10.2210/pdb3ke1/pdb |
Related | 3ieq 3ike 3ikf 3jvh 3k14 3k2x |
Descriptor | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 5'-deoxy-5'-[(pyridin-4-ylcarbonyl)amino]cytidine, ... (5 entities in total) |
Functional Keywords | niaid, ssgcid, seattle structural genomics center for infectious disease, fragment crystallography, fbdd, fragment-based drug-design, nucleoside analog, d000161829, isoprene biosynthesis, lyase, metal-binding |
Biological source | Burkholderia pseudomallei (Pseudomonas pseudomallei) |
Total number of polymer chains | 3 |
Total formula weight | 59738.63 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-10-23, release date: 2009-11-10, Last modification date: 2023-09-06) |
Primary citation | Zhang, Z.,Jakkaraju, S.,Blain, J.,Gogol, K.,Zhao, L.,Hartley, R.C.,Karlsson, C.A.,Staker, B.L.,Edwards, T.E.,Stewart, L.J.,Myler, P.J.,Clare, M.,Begley, D.W.,Horn, J.R.,Hagen, T.J. Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei. Bioorg.Med.Chem.Lett., 8:e53851-e53851, 2013 Cited by PubMed: 24157367DOI: 10.1016/j.bmcl.2013.09.101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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