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3K14

Co-crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with FOL fragment 535, ethyl 3-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate

Summary for 3K14
Entry DOI10.2210/pdb3k14/pdb
Related3F0E 3F0G 3IEQ 3IKE 3IKF 3JVH
Descriptor2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, ethyl 3-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate, ... (7 entities in total)
Functional Keywordsniaid, ssgcid, seattle structural genomics center for infectious disease, fragment crystallography, fragment-based drug-design, fbdd, fragments of life, isoprene biosynthesis, lyase, metal-binding
Biological sourceBurkholderia pseudomallei (Pseudomonas pseudomallei)
Total number of polymer chains3
Total formula weight59421.91
Authors
Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-09-25, release date: 2009-10-06, Last modification date: 2024-02-21)
Primary citationBegley, D.W.,Hartley, R.C.,Davies, D.R.,Edwards, T.E.,Leonard, J.T.,Abendroth, J.,Burris, C.A.,Bhandari, J.,Myler, P.J.,Staker, B.L.,Stewart, L.J.
Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
J Struct Funct Genomics, 12:63-76, 2011
Cited by
PubMed: 21359640
DOI: 10.1007/s10969-011-9102-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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