3IKF

Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with FOL fragment 717, imidazo[2,,1-b][1,3]thiazol-6-ylmethanol

Summary for 3IKF

• Entry DOI: 10.2210/pdb3ikf/pdb
• Related: 3F0D 3F0E 3F0F 3F0G 3IEQ 3IEW 3IKE
• Descriptor: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, imidazo[2,1-b][1,3]thiazol-6-ylmethanol, ... (7 entities in total)
• Functional Keywords: niaid, ssgcid, seattle structural genomics center for infectious disease, fragment-based drug design, fbdd, isoprene biosynthesis, lyase, metal-binding
• Biological source: Burkholderia pseudomallei (Pseudomonas pseudomallei)
• Total number of polymer chains: 3
• Total formula weight: 53280.04

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-08-05, release date: 2009-08-18, Last modification date: 2023-09-06)

• Primary citation: Begley, D.W.,Hartley, R.C.,Davies, D.R.,Edwards, T.E.,Leonard, J.T.,Abendroth, J.,Burris, C.A.,Bhandari, J.,Myler, P.J.,Staker, B.L.,Stewart, L.J.; Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.; J Struct Funct Genomics, 12:63-76, 2011; PubMed: 21359640; DOI: 10.1007/s10969-011-9102-6

Experimental method

X-RAY DIFFRACTION (2.07 Å)