3K2X

Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei in complex with 5'-iodo-cytosine

Summary for 3K2X

Entry DOI	10.2210/pdb3k2x/pdb
Related	3F0E 3IEQ 3IKE 3IKF 3JVH 3K14
Descriptor	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 5'-deoxy-5'-iodocytidine, ... (6 entities in total)
Functional Keywords	niaid, ssgcid, seattle structural genomics center for infectious disease, fragment-based drug design, fbdd, fragment crystallography, isoprene biosynthesis, lyase, metal-binding, fragments of life
Biological source	Burkholderia pseudomallei
Total number of polymer chains	3
Total formula weight	59791.45
Authors	Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-09-30, release date: 2009-10-13, Last modification date: 2024-02-21)
Primary citation	Begley, D.W.,Hartley, R.C.,Davies, D.R.,Edwards, T.E.,Leonard, J.T.,Abendroth, J.,Burris, C.A.,Bhandari, J.,Myler, P.J.,Staker, B.L.,Stewart, L.J. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics, 12:63-76, 2011 Cited by PubMed: 21359640 DOI: 10.1007/s10969-011-9102-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation