3KBT

Crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (ZU5-ANK)

3KBT の概要

• エントリーDOI: 10.2210/pdb3kbt/pdb
• 関連するPDBエントリー: 1U4Q 3EDU 3EDV 3F57 3F59 3KBU
• 分子名称: Spectrin beta chain, erythrocyte, Ankyrin-1 (2 entities in total)
• 機能のキーワード: complex, spectrin, spectrin repeat, three helix bundle, ankyrin binding, disease mutation, structural protein, ankyrin, zu5, beta sandwich, spectrin binding, cytoskeleton, membrane skeleton, actin capping, actin-binding, elliptocytosis, hereditary hemolytic anemia, phosphoprotein, alternative promoter usage, ank repeat, lipoprotein, membrane, sarcoplasmic reticulum
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton: P11277; Isoform Er1: Cytoplasm, cytoskeleton. Isoform Mu17: Membrane. Isoform Mu18: Sarcoplasmic reticulum . Isoform Mu19: Sarcoplasmic reticulum . Isoform Mu20: Sarcoplasmic reticulum : P16157
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 110261.83

構造登録者

Ipsaro, J.J.,Mondragon, A. (登録日: 2009-10-20, 公開日: 2010-02-02, 最終更新日: 2024-02-21)

• 主引用文献: Ipsaro, J.J.,Mondragon, A.; Structural basis for spectrin recognition by ankyrin.; Blood, 115:4093-4101, 2010; PubMed: 20101027; DOI: 10.1182/blood-2009-11-255604

実験手法

X-RAY DIFFRACTION (2.75 Å)