3KBT

Crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (ZU5-ANK)

Summary for 3KBT

Entry DOI	10.2210/pdb3kbt/pdb
Related	1U4Q 3EDU 3EDV 3F57 3F59 3KBU
Descriptor	Spectrin beta chain, erythrocyte, Ankyrin-1 (2 entities in total)
Functional Keywords	complex, spectrin, spectrin repeat, three helix bundle, ankyrin binding, disease mutation, structural protein, ankyrin, zu5, beta sandwich, spectrin binding, cytoskeleton, membrane skeleton, actin capping, actin-binding, elliptocytosis, hereditary hemolytic anemia, phosphoprotein, alternative promoter usage, ank repeat, lipoprotein, membrane, sarcoplasmic reticulum
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm, cytoskeleton: P11277 Isoform Er1: Cytoplasm, cytoskeleton. Isoform Mu17: Membrane. Isoform Mu18: Sarcoplasmic reticulum . Isoform Mu19: Sarcoplasmic reticulum . Isoform Mu20: Sarcoplasmic reticulum : P16157
Total number of polymer chains	4
Total formula weight	110261.83
Authors	Ipsaro, J.J.,Mondragon, A. (deposition date: 2009-10-20, release date: 2010-02-02, Last modification date: 2024-02-21)
Primary citation	Ipsaro, J.J.,Mondragon, A. Structural basis for spectrin recognition by ankyrin. Blood, 115:4093-4101, 2010 Cited by PubMed: 20101027 DOI: 10.1182/blood-2009-11-255604 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation