3JZP
Human MDMX liganded with a 12mer peptide inhibitor (pDI6W)
Summary for 3JZP
Entry DOI | 10.2210/pdb3jzp/pdb |
Related | 3JZO 3JZQ 3JZR 3JZS |
Descriptor | Protein Mdm4, pDI6W peptide (12mer), POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | cell cycle, p53-binding protein mdm4, double minute 4 protein, alternative splicing, metal-binding, nucleus, polymorphism, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O15151 |
Total number of polymer chains | 2 |
Total formula weight | 11719.67 |
Authors | Schonbrunn, E.,Phan, J. (deposition date: 2009-09-24, release date: 2009-11-10, Last modification date: 2023-09-06) |
Primary citation | Phan, J.,Li, Z.,Kasprzak, A.,Li, B.,Sebti, S.,Guida, W.,Schonbrunn, E.,Chen, J. Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285:2174-2183, 2010 Cited by PubMed: 19910468DOI: 10.1074/jbc.M109.073056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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