3JWZ

Structure of endothelial nitric oxide synthase heme domain complexed with N1-[(3' S,4' R)-4'-((6"-amino-4"-methylpyridin-2"-yl)methyl)pyrrolidin-3'-yl]-N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride

3JWZ の概要

• エントリーDOI: 10.2210/pdb3jwz/pdb
• 関連するPDBエントリー: 3JW0 3JW1 3JW2 3JW3 3JW4 3JW5 3JW6 3JWS 3JWT 3JWU 3JWV 3JWW 3JWX 3JWY
• 分子名称: Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total)
• 機能のキーワード: heme enzyme, substrate inhibitor, oxidoreductase
• 由来する生物種: Bos taurus (bovine)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102522.35

構造登録者

Delker, S.L.,Li, H.,Poulos, T.L. (登録日: 2009-09-18, 公開日: 2010-05-05, 最終更新日: 2024-02-21)

• 主引用文献: Delker, S.L.,Ji, H.,Li, H.,Jamal, J.,Fang, J.,Xue, F.,Silverman, R.B.,Poulos, T.L.; Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.; J.Am.Chem.Soc., 132:5437-5442, 2010; PubMed: 20337441; DOI: 10.1021/ja910228a

実験手法

X-RAY DIFFRACTION (2.4 Å)