3JWZ
Structure of endothelial nitric oxide synthase heme domain complexed with N1-[(3' S,4' R)-4'-((6"-amino-4"-methylpyridin-2"-yl)methyl)pyrrolidin-3'-yl]-N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Nitric oxide synthase, endothelial | polymer | 444 | 49710.1 | 2 | UniProt (P29473) Pfam (PF02898) In PDB | Bos taurus (bovine) | Endothelial NOS, eNOS, EC-NOS, NOS type III, NOSIII, Constitutive NOS, cNOS |
2 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
3 | A, B | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
4 | A, B | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
5 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
6 | A, B | N-{(3S,4R)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine | non-polymer | 371.5 | 2 | Chemie (J14) | |||
7 | A, B | CACODYLIC ACID | non-polymer | 138.0 | 2 | Chemie (CAD) | |||
8 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
9 | water | water | 18.0 | 300 | Chemie (HOH) |
Sequence modifications
A, B: 39 - 482 (UniProt: P29473)
PDB | External Database | Details |
---|---|---|
Arg 100 | Cys 100 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 99420.2 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 3102.1 | |
All* | Total formula weight | 102522.3 |