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3JWR

Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.

Summary for 3JWR
Entry DOI10.2210/pdb3jwr/pdb
Related3JWQ
DescriptorcGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ZINC ION, ... (6 entities in total)
Functional Keywordsmostly alpha, cgmp, hydrolase, polymorphism, sensory transduction, vision
Biological sourceHomo sapiens
More
Total number of polymer chains4
Total formula weight82225.69
Authors
Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O. (deposition date: 2009-09-18, release date: 2009-10-13, Last modification date: 2023-09-06)
Primary citationBarren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O.
Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
Embo J., 28:3613-3622, 2009
Cited by
PubMed: 19798052
DOI: 10.1038/emboj.2009.284
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.994 Å)
Structure validation

222926

數據於2024-07-24公開中

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