3JWR

Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.

Summary for 3JWR

• Entry DOI: 10.2210/pdb3jwr/pdb
• Related: 3JWQ
• Descriptor: cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ZINC ION, ... (6 entities in total)
• Functional Keywords: mostly alpha, cgmp, hydrolase, polymorphism, sensory transduction, vision
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 82225.69

Authors

Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O. (deposition date: 2009-09-18, release date: 2009-10-13, Last modification date: 2023-09-06)

• Primary citation: Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O.; Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit; Embo J., 28:3613-3622, 2009; PubMed: 19798052; DOI: 10.1038/emboj.2009.284

Experimental method

X-RAY DIFFRACTION (2.994 Å)