3JWR

Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.

3JWR の概要

• エントリーDOI: 10.2210/pdb3jwr/pdb
• 関連するPDBエントリー: 3JWQ
• 分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ZINC ION, ... (6 entities in total)
• 機能のキーワード: mostly alpha, cgmp, hydrolase, polymorphism, sensory transduction, vision
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 82225.69

構造登録者

Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O. (登録日: 2009-09-18, 公開日: 2009-10-13, 最終更新日: 2023-09-06)

• 主引用文献: Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O.; Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit; Embo J., 28:3613-3622, 2009; PubMed: 19798052; DOI: 10.1038/emboj.2009.284

実験手法

X-RAY DIFFRACTION (2.994 Å)