3JWQ
Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil
Summary for 3JWQ
Entry DOI | 10.2210/pdb3jwq/pdb |
Related | 3JWR |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | mostly alpha, allosteric enzyme, cgmp, cgmp-binding, hydrolase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, cell membrane, lipoprotein, membrane, methylation, prenylation, sensory transduction, vision |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 155385.50 |
Authors | Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O. (deposition date: 2009-09-18, release date: 2009-10-13, Last modification date: 2023-09-06) |
Primary citation | Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O. Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit Embo J., 28:3613-3622, 2009 Cited by PubMed: 19798052DOI: 10.1038/emboj.2009.284 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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