3JWQ

Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil

3JWQ の概要

• エントリーDOI: 10.2210/pdb3jwq/pdb
• 関連するPDBエントリー: 3JWR
• 分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: mostly alpha, allosteric enzyme, cgmp, cgmp-binding, hydrolase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, cell membrane, lipoprotein, membrane, methylation, prenylation, sensory transduction, vision
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 155385.50

構造登録者

Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O. (登録日: 2009-09-18, 公開日: 2009-10-13, 最終更新日: 2023-09-06)

• 主引用文献: Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O.; Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit; Embo J., 28:3613-3622, 2009; PubMed: 19798052; DOI: 10.1038/emboj.2009.284

実験手法

X-RAY DIFFRACTION (2.87 Å)