3J6X

S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II)

This is a large structure.

> Summary

Summary for 3J6X

Related3J6Y 3U5D
Integrates1VW7 1VW8 1VW9
EMDB informationEMD-5942 EMD-5943
DescriptorPROTEIN/RNA Complex
Functional Keywordstranslation initiation, ribosome, intergenic ires, tsv ires
Biological sourceSaccharomyces cerevisiae (yeast)
More
Cellular locationCytoplasm  P32905 P33442 P25443 P05750 P0CX35 P26783 P0CX37 P26786 P0CX39 O13516 Q08745 P0CX47 P48589 P05756 P06367 Q01855 P0CX51 P02407 P0CX55 P07280 P38701 P0C0V8 P0C0W1 P0CX29 P0CX31 Q3E792 P39938 P35997 Q3E7X9 P41057 P0CX33 P38011 P0CX43 P0CX45 P14126 P10664 P26321 Q02326 P05737 P17076 P05738 P41805 P0C0W9 Q12690 P36105 P05748 P26784 P05740 P0CX49 P0CX82 P0CX23 Q02753 P05749 P0CX41 P04449 P04456 P05743 P0C2H6 P02406 P05747 P14120 P0C2H8 P38061 P05744 P87262 P0CX84 P05745 P49166 P49167 P04650 P0CX86 P0CX27 P0CX25
Ubiquitin: Cytoplasm . 40S ribosomal protein S31: Cytoplasm  P05759
Ubiquitin: Cytoplasm . 60S ribosomal protein L40: Cytoplasm P0CH08
Total number of polymer chains80
Total molecular weight3194049.52
Authors
Koh, C.S.,Brilot, A.F.,Grigorieff, N.,Korostelev, A.A. (deposition date: 2014-04-16, release date: 2014-06-11, Last modification date: 2014-12-17)
Primary citation
Koh, C.S.,Brilot, A.F.,Grigorieff, N.,Korostelev, A.A.
Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center.
Proc.Natl.Acad.Sci.USA, 111:9139-9144, 2014
PubMed: 24927574
DOI: 10.1073/pnas.1406335111
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
?

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone274.5%7.9%0.48MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 3j6x
no rotation
Molmil generated image of 3j6x
rotated about x axis by 90°
Molmil generated image of 3j6x
rotated about y axis by 90°

> Structural details

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
2S25S ribosomal RNApolymer33951097149.91
Saccharomyces cerevisiae (yeast)
8S5.8S ribosomal RNApolymer15850683.31
Saccharomyces cerevisiae (yeast)
5S5S ribosomal RNApolymer12138951.41
Saccharomyces cerevisiae (yeast)
L160S ribosomal protein L1polymer21724525.01
UniProt (P0CX43)
Pfam (PF00687)
Saccharomyces cerevisiae (yeast)L10a
L260S ribosomal protein L2polymer25427463.81
UniProt (P0CX45)
Pfam (PF00181)
Pfam (PF03947)
Saccharomyces cerevisiae (yeast)L5, RP8, YL6
L360S ribosomal protein L3polymer38743851.31
UniProt (P14126)
Pfam (PF00297)
Saccharomyces cerevisiae (yeast)Maintenance of killer protein 8, RP1, Trichodermin resistance protein, YL1
L460S ribosomal protein L4polymer36239159.51
UniProt (P10664)
Pfam (PF00573)
Pfam (PF14374)
Saccharomyces cerevisiae (yeast)L2, RP2, YL2
L560S ribosomal protein L5polymer29733765.11
UniProt (P26321)
Pfam (PF14204)
Pfam (PF17144)
Saccharomyces cerevisiae (yeast)L1, L1a, Ribosomal 5S RNA-binding protein, YL3
L660S ribosomal protein L6polymer17620000.81
UniProt (Q02326)
Pfam (PF01159)
Saccharomyces cerevisiae (yeast)L17, RP18, YL16
L760S ribosomal protein L7polymer24427686.51
UniProt (P05737)
Pfam (PF00327)
Pfam (PF08079)
Saccharomyces cerevisiae (yeast)L6, RP11, YL8
L860S ribosomal protein L8polymer25628176.01
UniProt (P17076)
Pfam (PF01248)
Saccharomyces cerevisiae (yeast)L4, L4-2, L7a-1, Maintenance of killer protein 7, RP6, YL5
L960S ribosomal protein L9polymer19121605.21
UniProt (P05738)
Pfam (PF00347)
Saccharomyces cerevisiae (yeast)L8, RP24, YL11
5060S ribosomal protein L10polymer22125410.71
UniProt (P41805)
Pfam (PF00252)
Saccharomyces cerevisiae (yeast)L9, Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein
5160S ribosomal protein L11polymer17419755.91
UniProt (P0C0W9)
Pfam (PF00281)
Pfam (PF00673)
Saccharomyces cerevisiae (yeast)L16, RP39, YL22
5360S ribosomal protein L13polymer19922604.41
UniProt (Q12690)
Pfam (PF01294)
Saccharomyces cerevisiae (yeast)
5460S ribosomal protein L14polymer13815195.21
UniProt (P36105)
Pfam (PF01929)
Saccharomyces cerevisiae (yeast)
5560S ribosomal protein L15polymer20424482.61
UniProt (P05748)
Pfam (PF00827)
Saccharomyces cerevisiae (yeast)L13, RP15R, YL10, YP18
5660S ribosomal protein L16polymer19922247.41
UniProt (P26784)
Pfam (PF00572)
Saccharomyces cerevisiae (yeast)L13a, L21, RP22, YL15
5760S ribosomal protein L17polymer18420589.71
UniProt (P05740)
Pfam (PF00237)
Saccharomyces cerevisiae (yeast)L20A, YL17
5860S ribosomal protein L18polymer18620609.41
UniProt (P0CX49)
Pfam (PF17135)
Saccharomyces cerevisiae (yeast)RP28
5960S ribosomal protein L19polymer18921762.51
UniProt (P0CX82)
Pfam (PF01280)
Saccharomyces cerevisiae (yeast)L23, RP15L, RP33, YL14
6060S ribosomal protein L20polymer17220479.01
UniProt (P0CX23)
Pfam (PF01775)
Saccharomyces cerevisiae (yeast)L18a
6160S ribosomal protein L21polymer16018279.41
UniProt (Q02753)
Pfam (PF01157)
Saccharomyces cerevisiae (yeast)
6260S ribosomal protein L22polymer12113711.51
UniProt (P05749)
Pfam (PF01776)
Saccharomyces cerevisiae (yeast)L1c, RP4, YL31
6360S ribosomal protein L23polymer13714494.01
UniProt (P0CX41)
Pfam (PF00238)
Saccharomyces cerevisiae (yeast)L17a, YL32
6460S ribosomal protein L24polymer15517661.91
UniProt (P04449)
Pfam (PF01246)
Saccharomyces cerevisiae (yeast)L30, RP29, YL21
6560S ribosomal protein L25polymer14215787.81
UniProt (P04456)
Pfam (PF00276)
Pfam (PF03939)
Saccharomyces cerevisiae (yeast)RP16L, YL25, YP42'
6660S ribosomal protein L26polymer12714265.91
UniProt (P05743)
Pfam (PF00467)
Pfam (PF16906)
Saccharomyces cerevisiae (yeast)L33, YL33
6760S ribosomal protein L27polymer13615568.51
UniProt (P0C2H6)
Pfam (PF01777)
Saccharomyces cerevisiae (yeast)
6860S ribosomal protein L28polymer14916761.81
UniProt (P02406)
Pfam (PF00828)
Saccharomyces cerevisiae (yeast)L27a, L29, RP44, RP62, YL24
6960S ribosomal protein L29polymer596692.01
UniProt (P05747)
Pfam (PF01779)
Saccharomyces cerevisiae (yeast)YL43
7060S ribosomal protein L30polymer10511430.51
UniProt (P14120)
Pfam (PF01248)
Saccharomyces cerevisiae (yeast)L32, RP73, YL38
7160S ribosomal protein L31polymer11312980.31
UniProt (P0C2H8)
Pfam (PF01198)
Saccharomyces cerevisiae (yeast)L34, YL28
7260S ribosomal protein L32polymer13014809.61
UniProt (P38061)
Pfam (PF01655)
Saccharomyces cerevisiae (yeast)
7360S ribosomal protein L33polymer10712177.21
UniProt (P05744)
Pfam (PF01247)
Saccharomyces cerevisiae (yeast)L37, RP47, YL37
7460S ribosomal protein L34polymer12113673.31
UniProt (P87262)
Pfam (PF01199)
Saccharomyces cerevisiae (yeast)
7560S ribosomal protein L35polymer12013942.81
UniProt (P0CX84)
Pfam (PF00831)
Saccharomyces cerevisiae (yeast)
7660S ribosomal protein L36polymer10011151.41
UniProt (P05745)
Pfam (PF01158)
Saccharomyces cerevisiae (yeast)L39, YL39
7760S ribosomal protein L37polymer889877.51
UniProt (P49166)
Pfam (PF01907)
Saccharomyces cerevisiae (yeast)L43, YL35, YP55
7860S ribosomal protein L38polymer788845.61
UniProt (P49167)
Pfam (PF01781)
Saccharomyces cerevisiae (yeast)
7960S ribosomal protein L39polymer516358.71
UniProt (P04650)
Pfam (PF00832)
Saccharomyces cerevisiae (yeast)L46, YL40
8060S ribosomal protein L40polymer12814583.21
UniProt (P0CH08)
Pfam (PF00240)
Pfam (PF01020)
Saccharomyces cerevisiae (yeast)CEP52
8160S ribosomal protein L41polymer253354.31
UniProt (P0CX86)
Pfam (PF05162)
Saccharomyces cerevisiae (yeast)L47, YL41
8260S ribosomal protein L42polymer10612246.81
UniProt (P0CX27)
Pfam (PF00935)
Saccharomyces cerevisiae (yeast)L41, YL27, YP44
8360S ribosomal protein L43polymer9210113.01
UniProt (P0CX25)
Pfam (PF01780)
Saccharomyces cerevisiae (yeast)L37a, YL35
1S18S ribosomal RNApolymer1798579127.81
Saccharomyces cerevisiae (yeast)
S040S ribosomal protein S0polymer25228051.61
UniProt (P32905)
Pfam (PF00318)
Saccharomyces cerevisiae (yeast)Nucleic acid-binding protein NAB1A
S140S ribosomal protein S1polymer25528798.71
UniProt (P33442)
Pfam (PF01015)
Saccharomyces cerevisiae (yeast)RP10A
S240S ribosomal protein S2polymer25427491.01
UniProt (P25443)
Pfam (PF00333)
Pfam (PF03719)
Saccharomyces cerevisiae (yeast)Omnipotent suppressor protein SUP44, RP12, S4, YS5
S340S ribosomal protein S3polymer24026543.01
UniProt (P05750)
Pfam (PF00189)
Pfam (PF07650)
Saccharomyces cerevisiae (yeast)RP13, YS3
S440S ribosomal protein S4polymer26129469.61
UniProt (P0CX35)
Pfam (PF00467)
Pfam (PF00900)
Pfam (PF01479)
Pfam (PF08071)
Pfam (PF16121)
Saccharomyces cerevisiae (yeast)RP5, S7, YS6
S540S ribosomal protein S5polymer22525072.81
UniProt (P26783)
Pfam (PF00177)
Saccharomyces cerevisiae (yeast)RP14, S2, YS8
S640S ribosomal protein S6polymer23627054.71
UniProt (P0CX37)
Pfam (PF01092)
Saccharomyces cerevisiae (yeast)RP9, S10, YS4
S740S ribosomal protein S7polymer19021658.41
UniProt (P26786)
Pfam (PF01251)
Saccharomyces cerevisiae (yeast)RP30, RP40
S840S ribosomal protein S8polymer20022538.01
UniProt (P0CX39)
Pfam (PF01201)
Saccharomyces cerevisiae (yeast)RP19, S14, YS9
S940S ribosomal protein S9polymer19722488.11
UniProt (O13516)
Pfam (PF01479)
Saccharomyces cerevisiae (yeast)RP21, S13, YP28, YS11
1040S ribosomal protein S10polymer10512757.61
UniProt (Q08745)
Pfam (PF03501)
Saccharomyces cerevisiae (yeast)
1140S ribosomal protein S11polymer15617786.11
UniProt (P0CX47)
Pfam (PF00366)
Pfam (PF16205)
Saccharomyces cerevisiae (yeast)RP41, S18, YS12
1240S ribosomal protein S12polymer14315488.81
UniProt (P48589)
Pfam (PF01248)
Saccharomyces cerevisiae (yeast)
1340S ribosomal protein S13polymer15117060.11
UniProt (P05756)
Pfam (PF00312)
Pfam (PF08069)
Saccharomyces cerevisiae (yeast)S27a, YS15
1440S ribosomal protein S14polymer13714562.81
UniProt (P06367)
Pfam (PF00411)
Saccharomyces cerevisiae (yeast)RP59A
1540S ribosomal protein S15polymer14216032.01
UniProt (Q01855)
Pfam (PF00203)
Saccharomyces cerevisiae (yeast)RIG protein, RP52, S21, YS21
1640S ribosomal protein S16polymer14315877.61
UniProt (P0CX51)
Pfam (PF00380)
Saccharomyces cerevisiae (yeast)RP61R
1740S ribosomal protein S17polymer13615820.61
UniProt (P02407)
Pfam (PF00833)
Saccharomyces cerevisiae (yeast)RP51A
1840S ribosomal protein S18polymer14617071.81
UniProt (P0CX55)
Pfam (PF00416)
Saccharomyces cerevisiae (yeast)
1940S ribosomal protein S19polymer14415942.31
UniProt (P07280)
Pfam (PF01090)
Saccharomyces cerevisiae (yeast)RP55A, S16a, YP45, YS16A
2040S ribosomal protein S20polymer12113929.21
UniProt (P38701)
Pfam (PF00338)
Saccharomyces cerevisiae (yeast)
2140S ribosomal protein S21polymer879758.91
UniProt (P0C0V8)
Pfam (PF01249)
Saccharomyces cerevisiae (yeast)S26, YS25
2240S ribosomal protein S22polymer13014650.21
UniProt (P0C0W1)
Pfam (PF00410)
Saccharomyces cerevisiae (yeast)RP50, S24, YP58, YS22
2340S ribosomal protein S23polymer14516074.01
UniProt (P0CX29)
Pfam (PF00164)
Saccharomyces cerevisiae (yeast)RP37, S28, YS14
2440S ribosomal protein S24polymer13515363.01
UniProt (P0CX31)
Pfam (PF01282)
Saccharomyces cerevisiae (yeast)RP50
2540S ribosomal protein S25polymer10812067.41
UniProt (Q3E792)
Pfam (PF03297)
Saccharomyces cerevisiae (yeast)RP45, S31, YS23
2640S ribosomal protein S26polymer11913539.01
UniProt (P39938)
Pfam (PF01283)
Saccharomyces cerevisiae (yeast)
2740S ribosomal protein S27polymer828893.51
UniProt (P35997)
Pfam (PF01667)
Saccharomyces cerevisiae (yeast)RP61, YS20
2840S ribosomal protein S28polymer677605.91
UniProt (Q3E7X9)
Pfam (PF01200)
Saccharomyces cerevisiae (yeast)S33, YS27
2940S ribosomal protein S29polymer566675.81
UniProt (P41057)
Pfam (PF00253)
Saccharomyces cerevisiae (yeast)S36, YS29
3040S ribosomal protein S30polymer637137.61
UniProt (P0CX33)
Pfam (PF04758)
Saccharomyces cerevisiae (yeast)
3140S ribosomal protein S31polymer15217254.41
UniProt (P05759)
Pfam (PF00240)
Pfam (PF01599)
Saccharomyces cerevisiae (yeast)40S ribosomal protein S31, CEP76, S37, YS24
RAGuanine nucleotide-binding protein subunit beta-like proteinpolymer31934841.51
UniProt (P38011)
Pfam (PF00400)
Saccharomyces cerevisiae (yeast)Receptor for activated C kinase, Receptor of activated protein kinase C 1, RACK1
IRTSV IRES mRNApolymer20164644.71
Taura syndrome virus

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains80
Total molecular weight3194049.5
Non-Polymers*Number of molecules0
Total molecular weight0.0
All*Total molecular weight3194049.5
*Water molecules are not included.

> Experimental details

Refinement Statistics

Experimental method:ELECTRON MICROSCOPY

Cell axes1.0001.0001.000
Cell angles90.0090.0090.00
SpacegroupP 1
Resolution limits -
the highest resolution shell value -

Data Collection Statistics

Resolution limits -
the highest resolution shell value -

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
Annotated Information is extracted from Literature Info*

> Functional details

?

Functional Information from GO Data

ChainGOidnamespacecontents
RA0022627cellular_componentcytosolic small ribosomal subunit
RA0001965molecular_functionG-protein alpha-subunit binding
RA0005092molecular_functionGDP-dissociation inhibitor activity
RA0004871molecular_functionsignal transducer activity
RA0007186biological_processG-protein coupled receptor signaling pathway
RA0001403biological_processinvasive growth in response to glucose limitation
RA1902660biological_processnegative regulation of glucose mediated signaling pathway
RA0017148biological_processnegative regulation of translation
RA2001125biological_processnegative regulation of translational frameshifting
500022625cellular_componentcytosolic large ribosomal subunit
500003735molecular_functionstructural constituent of ribosome
500002181biological_processcytoplasmic translation
500000027biological_processribosomal large subunit assembly
500006415biological_processtranslational termination
510022625cellular_componentcytosolic large ribosomal subunit
510005634cellular_componentnucleus
510019843molecular_functionrRNA binding
510003735molecular_functionstructural constituent of ribosome
510002181biological_processcytoplasmic translation
510000027biological_processribosomal large subunit assembly
510006412biological_processtranslation
530022625cellular_componentcytosolic large ribosomal subunit
530003723molecular_functionRNA binding
530003735molecular_functionstructural constituent of ribosome
530002181biological_processcytoplasmic translation
530006412biological_processtranslation
540022625cellular_componentcytosolic large ribosomal subunit
540003723molecular_functionRNA binding
540003735molecular_functionstructural constituent of ribosome
540002181biological_processcytoplasmic translation
540016236biological_processmacroautophagy
550022625cellular_componentcytosolic large ribosomal subunit
550003723molecular_functionRNA binding
550003735molecular_functionstructural constituent of ribosome
550002181biological_processcytoplasmic translation
560022625cellular_componentcytosolic large ribosomal subunit
560003729molecular_functionmRNA binding
560003723molecular_functionRNA binding
560003735molecular_functionstructural constituent of ribosome
560002181biological_processcytoplasmic translation
560006412biological_processtranslation
570022625cellular_componentcytosolic large ribosomal subunit
570030687cellular_componentpreribosome, large subunit precursor
570003735molecular_functionstructural constituent of ribosome
570000448biological_processcleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
570002181biological_processcytoplasmic translation
580022625cellular_componentcytosolic large ribosomal subunit
580003735molecular_functionstructural constituent of ribosome
580002181biological_processcytoplasmic translation
590022625cellular_componentcytosolic large ribosomal subunit
590003735molecular_functionstructural constituent of ribosome
590002181biological_processcytoplasmic translation
590006412biological_processtranslation
L10022625cellular_componentcytosolic large ribosomal subunit
L10003723molecular_functionRNA binding
L10003735molecular_functionstructural constituent of ribosome
L10002181biological_processcytoplasmic translation
L10000470biological_processmaturation of LSU-rRNA
L10006412biological_processtranslation
600022625cellular_componentcytosolic large ribosomal subunit
600003735molecular_functionstructural constituent of ribosome
600002181biological_processcytoplasmic translation
600006412biological_processtranslation
610022625cellular_componentcytosolic large ribosomal subunit
610003735molecular_functionstructural constituent of ribosome
610002181biological_processcytoplasmic translation
610006412biological_processtranslation
620022625cellular_componentcytosolic large ribosomal subunit
620003735molecular_functionstructural constituent of ribosome
620002181biological_processcytoplasmic translation
630022625cellular_componentcytosolic large ribosomal subunit
630070180molecular_functionlarge ribosomal subunit rRNA binding
630003735molecular_functionstructural constituent of ribosome
630002181biological_processcytoplasmic translation
640022625cellular_componentcytosolic large ribosomal subunit
640003723molecular_functionRNA binding
640003735molecular_functionstructural constituent of ribosome
641902626biological_processassembly of large subunit precursor of preribosome
640002181biological_processcytoplasmic translation
640000027biological_processribosomal large subunit assembly
640006412biological_processtranslation
650022625cellular_componentcytosolic large ribosomal subunit
650030687cellular_componentpreribosome, large subunit precursor
650003723molecular_functionRNA binding
650019843molecular_functionrRNA binding
650003735molecular_functionstructural constituent of ribosome
650002181biological_processcytoplasmic translation
650000027biological_processribosomal large subunit assembly
650006412biological_processtranslation
660022625cellular_componentcytosolic large ribosomal subunit
660003723molecular_functionRNA binding
660003735molecular_functionstructural constituent of ribosome
660002181biological_processcytoplasmic translation
670022625cellular_componentcytosolic large ribosomal subunit
670003735molecular_functionstructural constituent of ribosome
670002181biological_processcytoplasmic translation
680022625cellular_componentcytosolic large ribosomal subunit
680005634cellular_componentnucleus
680003723molecular_functionRNA binding
680003735molecular_functionstructural constituent of ribosome
680002181biological_processcytoplasmic translation
680046677biological_processresponse to antibiotic
680046898biological_processresponse to cycloheximide
690022625cellular_componentcytosolic large ribosomal subunit
690003735molecular_functionstructural constituent of ribosome
690002181biological_processcytoplasmic translation
L20022625cellular_componentcytosolic large ribosomal subunit
L20019843molecular_functionrRNA binding
L20003735molecular_functionstructural constituent of ribosome
L20002181biological_processcytoplasmic translation
700005737cellular_componentcytoplasm
700022625cellular_componentcytosolic large ribosomal subunit
700030627molecular_functionpre-mRNA 5'-splice site binding
700003723molecular_functionRNA binding
700003735molecular_functionstructural constituent of ribosome
700002181biological_processcytoplasmic translation
700048025biological_processnegative regulation of mRNA splicing, via spliceosome
700006364biological_processrRNA processing
710022625cellular_componentcytosolic large ribosomal subunit
710003735molecular_functionstructural constituent of ribosome
710002181biological_processcytoplasmic translation
710006450biological_processregulation of translational fidelity
720022625cellular_componentcytosolic large ribosomal subunit
720003735molecular_functionstructural constituent of ribosome
720002181biological_processcytoplasmic translation
730022625cellular_componentcytosolic large ribosomal subunit
730003735molecular_functionstructural constituent of ribosome
730002181biological_processcytoplasmic translation
740022625cellular_componentcytosolic large ribosomal subunit
740030687cellular_componentpreribosome, large subunit precursor
740003723molecular_functionRNA binding
740003735molecular_functionstructural constituent of ribosome
740002181biological_processcytoplasmic translation
740042254biological_processribosome biogenesis
740006412biological_processtranslation
750022625cellular_componentcytosolic large ribosomal subunit
750030687cellular_componentpreribosome, large subunit precursor
750003729molecular_functionmRNA binding
750003735molecular_functionstructural constituent of ribosome
750002181biological_processcytoplasmic translation
750000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
750006412biological_processtranslation
760022625cellular_componentcytosolic large ribosomal subunit
760003723molecular_functionRNA binding
760003735molecular_functionstructural constituent of ribosome
760002181biological_processcytoplasmic translation
770022625cellular_componentcytosolic large ribosomal subunit
770030687cellular_componentpreribosome, large subunit precursor
770046872molecular_functionmetal ion binding
770003723molecular_functionRNA binding
770019843molecular_functionrRNA binding
770003735molecular_functionstructural constituent of ribosome
770000448biological_processcleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
770002181biological_processcytoplasmic translation
770006412biological_processtranslation
780022625cellular_componentcytosolic large ribosomal subunit
780003735molecular_functionstructural constituent of ribosome
780002181biological_processcytoplasmic translation
790022625cellular_componentcytosolic large ribosomal subunit
790003723molecular_functionRNA binding
790003735molecular_functionstructural constituent of ribosome
790002181biological_processcytoplasmic translation
790006412biological_processtranslation
L30022625cellular_componentcytosolic large ribosomal subunit
L30003735molecular_functionstructural constituent of ribosome
L30002181biological_processcytoplasmic translation
L30000027biological_processribosomal large subunit assembly
800022625cellular_componentcytosolic large ribosomal subunit
800005634cellular_componentnucleus
800031386molecular_functionprotein tag
800003735molecular_functionstructural constituent of ribosome
800002181biological_processcytoplasmic translation
800016567biological_processprotein ubiquitination
800000027biological_processribosomal large subunit assembly
800000055biological_processribosomal large subunit export from nucleus
800042254biological_processribosome biogenesis
810022625cellular_componentcytosolic large ribosomal subunit
810003735molecular_functionstructural constituent of ribosome
810002181biological_processcytoplasmic translation
830022625cellular_componentcytosolic large ribosomal subunit
830046872molecular_functionmetal ion binding
830003735molecular_functionstructural constituent of ribosome
830002181biological_processcytoplasmic translation
820022625cellular_componentcytosolic large ribosomal subunit
820003735molecular_functionstructural constituent of ribosome
820002181biological_processcytoplasmic translation
820046677biological_processresponse to antibiotic
820046898biological_processresponse to cycloheximide
L40022625cellular_componentcytosolic large ribosomal subunit
L40005634cellular_componentnucleus
L40003723molecular_functionRNA binding
L40003735molecular_functionstructural constituent of ribosome
L40002181biological_processcytoplasmic translation
L50022625cellular_componentcytosolic large ribosomal subunit
L50005634cellular_componentnucleus
L50008097molecular_function5S rRNA binding
L50003735molecular_functionstructural constituent of ribosome
L50002181biological_processcytoplasmic translation
L50000027biological_processribosomal large subunit assembly
L50006412biological_processtranslation
L60022625cellular_componentcytosolic large ribosomal subunit
L60003723molecular_functionRNA binding
L60003735molecular_functionstructural constituent of ribosome
L60002181biological_processcytoplasmic translation
L60000027biological_processribosomal large subunit assembly
L70005737cellular_componentcytoplasm
L70022625cellular_componentcytosolic large ribosomal subunit
L70003735molecular_functionstructural constituent of ribosome
L70002181biological_processcytoplasmic translation
L70000470biological_processmaturation of LSU-rRNA
L70000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L70042273biological_processribosomal large subunit biogenesis
L80022625cellular_componentcytosolic large ribosomal subunit
L80003723molecular_functionRNA binding
L80003735molecular_functionstructural constituent of ribosome
L80002181biological_processcytoplasmic translation
L80000470biological_processmaturation of LSU-rRNA
L80006412biological_processtranslation
L90022625cellular_componentcytosolic large ribosomal subunit
L90003723molecular_functionRNA binding
L90019843molecular_functionrRNA binding
L90003735molecular_functionstructural constituent of ribosome
L90002181biological_processcytoplasmic translation
100022627cellular_componentcytosolic small ribosomal subunit
100003735molecular_functionstructural constituent of ribosome
100034198biological_processcellular response to amino acid starvation
100002181biological_processcytoplasmic translation
100045860biological_processpositive regulation of protein kinase activity
100000028biological_processribosomal small subunit assembly
100006407biological_processrRNA export from nucleus
110022627cellular_componentcytosolic small ribosomal subunit
110019843molecular_functionrRNA binding
110003735molecular_functionstructural constituent of ribosome
110002181biological_processcytoplasmic translation
110000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
110000028biological_processribosomal small subunit assembly
110006412biological_processtranslation
120022627cellular_componentcytosolic small ribosomal subunit
120003735molecular_functionstructural constituent of ribosome
120002181biological_processcytoplasmic translation
130022627cellular_componentcytosolic small ribosomal subunit
130005730cellular_componentnucleolus
130070181molecular_functionsmall ribosomal subunit rRNA binding
130003735molecular_functionstructural constituent of ribosome
130002181biological_processcytoplasmic translation
130000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
130006412biological_processtranslation
140022627cellular_componentcytosolic small ribosomal subunit
140005730cellular_componentnucleolus
140005654cellular_componentnucleoplasm
140032040cellular_componentsmall-subunit processome
140048027molecular_functionmRNA 5'-UTR binding
140003729molecular_functionmRNA binding
140070181molecular_functionsmall ribosomal subunit rRNA binding
140003735molecular_functionstructural constituent of ribosome
140002181biological_processcytoplasmic translation
140000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
140000028biological_processribosomal small subunit assembly
140031167biological_processrRNA methylation
140006412biological_processtranslation
150022627cellular_componentcytosolic small ribosomal subunit
150003723molecular_functionRNA binding
150003735molecular_functionstructural constituent of ribosome
150002181biological_processcytoplasmic translation
150000028biological_processribosomal small subunit assembly
150006407biological_processrRNA export from nucleus
160022627cellular_componentcytosolic small ribosomal subunit
160003735molecular_functionstructural constituent of ribosome
160002181biological_processcytoplasmic translation
160000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
160006412biological_processtranslation
170022627cellular_componentcytosolic small ribosomal subunit
170003735molecular_functionstructural constituent of ribosome
170002181biological_processcytoplasmic translation
170000028biological_processribosomal small subunit assembly
180005829cellular_componentcytosol
180022627cellular_componentcytosolic small ribosomal subunit
180015935cellular_componentsmall ribosomal subunit
180019843molecular_functionrRNA binding
180003735molecular_functionstructural constituent of ribosome
180002181biological_processcytoplasmic translation
180000447biological_processendonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
180006407biological_processrRNA export from nucleus
180006412biological_processtranslation
190022627cellular_componentcytosolic small ribosomal subunit
190003735molecular_functionstructural constituent of ribosome
190002181biological_processcytoplasmic translation
190000028biological_processribosomal small subunit assembly
190042274biological_processribosomal small subunit biogenesis
190006407biological_processrRNA export from nucleus
200022627cellular_componentcytosolic small ribosomal subunit
200003723molecular_functionRNA binding
200003735molecular_functionstructural constituent of ribosome
200002181biological_processcytoplasmic translation
200000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
210022627cellular_componentcytosolic small ribosomal subunit
210003735molecular_functionstructural constituent of ribosome
210002181biological_processcytoplasmic translation
210000447biological_processendonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
210000461biological_processendonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
220022627cellular_componentcytosolic small ribosomal subunit
220003735molecular_functionstructural constituent of ribosome
220002181biological_processcytoplasmic translation
230022627cellular_componentcytosolic small ribosomal subunit
230003735molecular_functionstructural constituent of ribosome
230000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
230006450biological_processregulation of translational fidelity
230006412biological_processtranslation
240022627cellular_componentcytosolic small ribosomal subunit
240003735molecular_functionstructural constituent of ribosome
240002181biological_processcytoplasmic translation
240000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
250022627cellular_componentcytosolic small ribosomal subunit
250003735molecular_functionstructural constituent of ribosome
250002181biological_processcytoplasmic translation
260022627cellular_componentcytosolic small ribosomal subunit
260003729molecular_functionmRNA binding
260003735molecular_functionstructural constituent of ribosome
260002181biological_processcytoplasmic translation
260042255biological_processribosome assembly
260006407biological_processrRNA export from nucleus
270022627cellular_componentcytosolic small ribosomal subunit
270046872molecular_functionmetal ion binding
270003735molecular_functionstructural constituent of ribosome
270002181biological_processcytoplasmic translation
270000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
270000028biological_processribosomal small subunit assembly
270006412biological_processtranslation
280022627cellular_componentcytosolic small ribosomal subunit
280003723molecular_functionRNA binding
280003735molecular_functionstructural constituent of ribosome
280002181biological_processcytoplasmic translation
280030490biological_processmaturation of SSU-rRNA
281900153biological_processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
280000028biological_processribosomal small subunit assembly
280006407biological_processrRNA export from nucleus
290022627cellular_componentcytosolic small ribosomal subunit
290003735molecular_functionstructural constituent of ribosome
290008270molecular_functionzinc ion binding
290002181biological_processcytoplasmic translation
S20022627cellular_componentcytosolic small ribosomal subunit
S20005730cellular_componentnucleolus
S20005654cellular_componentnucleoplasm
S20032040cellular_componentsmall-subunit processome
S20070181molecular_functionsmall ribosomal subunit rRNA binding
S20003735molecular_functionstructural constituent of ribosome
S20045903biological_processpositive regulation of translational fidelity
S20006407biological_processrRNA export from nucleus
S20031167biological_processrRNA methylation
S20006412biological_processtranslation
300010494cellular_componentcytoplasmic stress granule
300022627cellular_componentcytosolic small ribosomal subunit
300003735molecular_functionstructural constituent of ribosome
300002181biological_processcytoplasmic translation
310022627cellular_componentcytosolic small ribosomal subunit
310005634cellular_componentnucleus
310046872molecular_functionmetal ion binding
310031386molecular_functionprotein tag
310003735molecular_functionstructural constituent of ribosome
310002181biological_processcytoplasmic translation
310002109biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
310000028biological_processribosomal small subunit assembly
310042254biological_processribosome biogenesis
S10005829cellular_componentcytosol
S10022627cellular_componentcytosolic small ribosomal subunit
S10003735molecular_functionstructural constituent of ribosome
S10002181biological_processcytoplasmic translation
S10000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S30022627cellular_componentcytosolic small ribosomal subunit
S30005634cellular_componentnucleus
S30030688cellular_componentpreribosome, small subunit precursor
S30003684molecular_functiondamaged DNA binding
S30003906molecular_functionDNA-(apurinic or apyrimidinic site) lyase activity
S30008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
S30003723molecular_functionRNA binding
S30003735molecular_functionstructural constituent of ribosome
S30002181biological_processcytoplasmic translation
S30006281biological_processDNA repair
S30000056biological_processribosomal small subunit export from nucleus
S30006407biological_processrRNA export from nucleus
S40022627cellular_componentcytosolic small ribosomal subunit
S40019843molecular_functionrRNA binding
S40003735molecular_functionstructural constituent of ribosome
S40002181biological_processcytoplasmic translation
S40006412biological_processtranslation
S50022627cellular_componentcytosolic small ribosomal subunit
S50003723molecular_functionRNA binding
S50003735molecular_functionstructural constituent of ribosome
S50002181biological_processcytoplasmic translation
S50006450biological_processregulation of translational fidelity
S50006407biological_processrRNA export from nucleus
S60022627cellular_componentcytosolic small ribosomal subunit
S60005730cellular_componentnucleolus
S60005654cellular_componentnucleoplasm
S60032040cellular_componentsmall-subunit processome
S60003735molecular_functionstructural constituent of ribosome
S60002181biological_processcytoplasmic translation
S60000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S60031167biological_processrRNA methylation
S70022627cellular_componentcytosolic small ribosomal subunit
S70005730cellular_componentnucleolus
S70005654cellular_componentnucleoplasm
S70032040cellular_componentsmall-subunit processome
S70003735molecular_functionstructural constituent of ribosome
S70002181biological_processcytoplasmic translation
S70042254biological_processribosome biogenesis
S70031167biological_processrRNA methylation
S80022627cellular_componentcytosolic small ribosomal subunit
S80003735molecular_functionstructural constituent of ribosome
S80002181biological_processcytoplasmic translation
S80000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S90022627cellular_componentcytosolic small ribosomal subunit
S90005730cellular_componentnucleolus
S90005654cellular_componentnucleoplasm
S90032040cellular_componentsmall-subunit processome
S90019843molecular_functionrRNA binding
S90003735molecular_functionstructural constituent of ribosome
S90002181biological_processcytoplasmic translation
S90000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S90045903biological_processpositive regulation of translational fidelity
S90031167biological_processrRNA methylation
S00010494cellular_componentcytoplasmic stress granule
S00022627cellular_componentcytosolic small ribosomal subunit
S00003735molecular_functionstructural constituent of ribosome
S00002181biological_processcytoplasmic translation
S00000447biological_processendonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S00000461biological_processendonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S00000028biological_processribosomal small subunit assembly
S00006407biological_processrRNA export from nucleus
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Functional Information from PDB Data

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

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Functional Information from PROSITE/UniProt

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Functional Information from SwissProt/UniProt

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Catalytic Information from CSA

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> Sequence Neighbor

Sequence navigator - 3j6x: Chain 2S
Sequence navigator - 3j6x: Chain 8S
Sequence navigator - 3j6x: Chain 5S
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Sequence navigator - 3j6x: Chain 50
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Sequence navigator - 3j6x: Chain 1S
Sequence navigator - 3j6x: Chain S0
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Sequence navigator - 3j6x: Chain 31
Sequence navigator - 3j6x: Chain RA
Sequence navigator - 3j6x: Chain IR

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