3ITH
Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor
Summary for 3ITH
Entry DOI | 10.2210/pdb3ith/pdb |
Related | 3ISN |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 6-ethenyl-N,N-dimethyl-2-(methylsulfonyl)pyrimidin-4-amine (3 entities in total) |
Functional Keywords | hiv-1, inhibitor, rt, transferase, hydrolase |
Biological source | Human immunodeficiency virus (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 4 |
Total formula weight | 229341.50 |
Authors | |
Primary citation | Freisz, S.,Bec, G.,Radi, M.,Wolff, P.,Crespan, E.,Angeli, L.,Dumas, P.,Maga, G.,Botta, M.,Ennifar, E. Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action Angew.Chem.Int.Ed.Engl., 49:1805-1808, 2010 Cited by PubMed: 20135654DOI: 10.1002/anie.200905651 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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