3ITH
Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| C | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| C | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| D | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| D | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDM C 561 |
| Chain | Residue |
| C | MET230 |
| C | GLY231 |
| C | LYS263 |
| C | TRP266 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDM A 561 |
| Chain | Residue |
| A | LYS263 |
| A | TRP266 |
| A | TYR183 |
| A | MET184 |
| A | MET230 |
| A | GLN242 |
| A | GLY262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ASP110 | |
| B | ASP185 | |
| B | ASP186 | |
| D | ASP110 | |
| D | ASP185 | |
| D | ASP186 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Essential for RT p66/p51 heterodimerization |
| Chain | Residue | Details |
| B | TRP401 | |
| B | TRP414 | |
| D | TRP401 | |
| D | TRP414 | |
| C | ASP443 | |
| C | GLN478 | |
| C | ASP498 | |
| C | ASP549 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Essential for RT p66/p51 heterodimerization |
| Chain | Residue | Details |
| A | TRP401 | |
| A | TRP414 | |
| C | TRP401 | |
| C | TRP414 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease; partial |
| Chain | Residue | Details |
| A | PHE440 | |
| C | PHE440 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU560 | |
| C | LEU560 |
