3ITH
Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Reverse transcriptase/ribonuclease H | polymer | 560 | 64516.0 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus (HIV-1) | HIV-1 reverse transcriptase, p66 RT |
2 | B, D | p51 RT | polymer | 427 | 49927.4 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus (HIV-1) | |
3 | A, C | 6-ethenyl-N,N-dimethyl-2-(methylsulfonyl)pyrimidin-4-amine | non-polymer | 227.3 | 2 | Chemie (EDM) |
Sequence modifications
A, C: 1 - 560 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Gln 478 | Glu 1077 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 228886.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 454.6 | |
All* | Total formula weight | 229341.5 |