3ITH
Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Reverse transcriptase/ribonuclease H | polymer | 560 | 64516.0 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus (HIV-1) | HIV-1 reverse transcriptase, p66 RT |
| 2 | B, D (B, D) | p51 RT | polymer | 427 | 49927.4 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus (HIV-1) | |
| 3 | E, F (A, C) | 6-ethenyl-N,N-dimethyl-2-(methylsulfonyl)pyrimidin-4-amine | non-polymer | 227.3 | 2 | Chemie (EDM) |
Sequence modifications
A, C: 1 - 560 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Gln 478 | Glu 1077 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 228886.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 454.6 | |
| All* | Total formula weight | 229341.5 |
