3IOJ
Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with UDP
Summary for 3IOJ
Entry DOI | 10.2210/pdb3ioj/pdb |
Related | 1LZ0 3IOH 3IOI |
Descriptor | Histo-blood group ABO system transferase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | gta, abo, cisab mutant, aa(gly)b, rossmann fold, udp, semi-closed conformation, blood group antigen, glycoprotein, glycosyltransferase, golgi apparatus, manganese, membrane, metal-binding, polymorphism, secreted, signal-anchor, transferase, transmembrane |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442 |
Total number of polymer chains | 2 |
Total formula weight | 70794.65 |
Authors | Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. (deposition date: 2009-08-14, release date: 2010-04-07, Last modification date: 2023-09-06) |
Primary citation | Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. Structural and mechanistic basis for a new mode of glycosyltransferase inhibition. Nat.Chem.Biol., 6:321-323, 2010 Cited by PubMed: 20364127DOI: 10.1038/nchembio.343 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.651 Å) |
Structure validation
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