3IOJ

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with UDP

3IOJ の概要

• エントリーDOI: 10.2210/pdb3ioj/pdb
• 関連するPDBエントリー: 1LZ0 3IOH 3IOI
• 分子名称: Histo-blood group ABO system transferase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: gta, abo, cisab mutant, aa(gly)b, rossmann fold, udp, semi-closed conformation, blood group antigen, glycoprotein, glycosyltransferase, golgi apparatus, manganese, membrane, metal-binding, polymorphism, secreted, signal-anchor, transferase, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70794.65

構造登録者

Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. (登録日: 2009-08-14, 公開日: 2010-04-07, 最終更新日: 2023-09-06)

• 主引用文献: Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K.; Structural and mechanistic basis for a new mode of glycosyltransferase inhibition.; Nat.Chem.Biol., 6:321-323, 2010; PubMed: 20364127; DOI: 10.1038/nchembio.343

実験手法

X-RAY DIFFRACTION (1.651 Å)