3IOH
Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A)
Summary for 3IOH
| Entry DOI | 10.2210/pdb3ioh/pdb |
| Related | 1LZ0 3IOI 3IOJ |
| Descriptor | Histo-blood group ABO system transferase, GLYCEROL (3 entities in total) |
| Functional Keywords | gta, abo, cisab mutant, aa(gly)b, rossmann fold, unliganded, open conformation, blood group antigen, glycoprotein, glycosyltransferase, golgi apparatus, manganese, membrane, metal-binding, polymorphism, secreted, signal-anchor, transferase, transmembrane |
| Biological source | Homo sapiens (human) |
| Cellular location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442 |
| Total number of polymer chains | 1 |
| Total formula weight | 34746.10 |
| Authors | Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. (deposition date: 2009-08-14, release date: 2010-04-07, Last modification date: 2023-09-06) |
| Primary citation | Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. Structural and mechanistic basis for a new mode of glycosyltransferase inhibition. Nat.Chem.Biol., 6:321-323, 2010 Cited by PubMed Abstract: Glycosyltransferases are carbohydrate-active enzymes with essential roles in numerous important biological processes. We have developed a new donor analog for galactosyltransferases that locks a representative target enzyme in a catalytically inactive conformation, thus almost completely abolishing sugar transfer. Results with other galactosyltransferases suggest that this unique mode of glycosyltransferase inhibition may also be generally applicable to other members of this important enzyme family. PubMed: 20364127DOI: 10.1038/nchembio.343 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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