3IMU
Transthyretin in complex with (E)-4-(3-aminostyryl)-2,6-dibromoaniline
Summary for 3IMU
Entry DOI | 10.2210/pdb3imu/pdb |
Related | 2QGB 2QGC 2QGD 2QGE 3ESO 3ESP 3IMR 3IMS 3IMT 3IMV 3IMW |
Descriptor | Transthyretin, 4-[(E)-2-(3-aminophenyl)ethenyl]-2,6-dibromoaniline (3 entities in total) |
Functional Keywords | hormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28290.85 |
Authors | Connelly, S.,Wilson, I.A. (deposition date: 2009-08-11, release date: 2010-01-12, Last modification date: 2023-09-06) |
Primary citation | Choi, S.,Reixach, N.,Connelly, S.,Johnson, S.M.,Wilson, I.A.,Kelly, J.W. A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132:1359-1370, 2010 Cited by PubMed: 20043671DOI: 10.1021/ja908562q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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