2QGE
Human transthyretin (TTR) complexed with 2-(3,5-Dimethylphenyl)benzoxazole
Summary for 2QGE
Entry DOI | 10.2210/pdb2qge/pdb |
Descriptor | Transthyretin, 2-(3,5-DIMETHYLPHENYL)-1,3-BENZOXAZOLE (3 entities in total) |
Functional Keywords | transthyretin, tetramer, amyloidogenesis inhibitors, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28001.26 |
Authors | Connelly, S.,Wilson, I.A. (deposition date: 2007-06-28, release date: 2008-02-05, Last modification date: 2023-08-30) |
Primary citation | Johnson, S.M.,Connelly, S.,Wilson, I.A.,Kelly, J.W. Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. J.Med.Chem., 51:260-270, 2008 Cited by PubMed: 18095641DOI: 10.1021/jm0708735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
Download full validation report