3ESO

Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,5-dichlorobenzamide

Summary for 3ESO

Entry DOI	10.2210/pdb3eso/pdb
Related	3ESN 3ESP
Descriptor	Transthyretin, 2,5-dichloro-N-(3,5-dibromo-4-hydroxyphenyl)benzamide (3 entities in total)
Functional Keywords	hormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28434.55
Authors	Connelly, S.,Wilson, I.A. (deposition date: 2008-10-06, release date: 2009-04-07, Last modification date: 2023-12-27)
Primary citation	Johnson, S.M.,Connelly, S.,Wilson, I.A.,Kelly, J.W. Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 52:1115-1125, 2009 Cited by PubMed: 19191553 DOI: 10.1021/jm801347s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.31 Å)

Structure validation