3IA9

Crystal structure of a chemically synthesized [D25N]HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor

3IA9 の概要

• エントリーDOI: 10.2210/pdb3ia9/pdb
• 関連するPDBエントリー: 3FSM 3HAU 3HAW 3HBO 3HDK 3HLO
• 関連するBIRD辞書のPRD_ID: PRD_000398
• 分子名称: [D25N]HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: beta-sheet, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22482.39

構造登録者

Torbeev, V.Y.,Kent, S.B.H. (登録日: 2009-07-13, 公開日: 2011-07-27, 最終更新日: 2012-12-12)

• 主引用文献: Torbeev, V.Y.,Kent, S.B.H.; Hydrogen bonds at the protein-inhibitor interface in the HIV-1 protease / inhibitors complexes probed by total chemical synthesis and X-ray crystallography; To be Published,

実験手法

X-RAY DIFFRACTION (1.3 Å)