3I3A

Structural Basis for the Sugar Nucleotide and Acyl Chain Selectivity of Leptospira interrogans LpxA

Summary for 3I3A

• Entry DOI: 10.2210/pdb3i3a/pdb
• Related: 3HSQ 3I3X
• Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, S-[2-({N-[(2R)-2-hydroxy-4-{[(S)-hydroxy(methoxy)phosphoryl]oxy}-3,3-dimethylbutanoyl]-beta-alanyl}amino)ethyl] (3R)-3-hydroxydodecanethioate (3 entities in total)
• Functional Keywords: lpxa, leptospira interrogans, leptospira interrogans complex, acyltransferase, lipid a biosynthesis, lipid synthesis, transferase
• Biological source: Leptospira interrogans
• Cellular location: Cytoplasm (By similarity): Q8EZA6
• Total number of polymer chains: 3
• Total formula weight: 86318.29

Authors

Williams, A.H. (deposition date: 2009-06-30, release date: 2009-09-01, Last modification date: 2024-02-21)

• Primary citation: Robins, L.I.,Williams, A.H.,Raetz, C.R.; Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA.; Biochemistry, 48:6191-6201, 2009; PubMed: 19456129; DOI: 10.1021/bi900629e

Experimental method

X-RAY DIFFRACTION (2.12 Å)