3I3A
Structural Basis for the Sugar Nucleotide and Acyl Chain Selectivity of Leptospira interrogans LpxA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| C | 0008610 | biological_process | lipid biosynthetic process |
| C | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE S2N A 260 |
| Chain | Residue |
| A | GLN68 |
| A | GLN156 |
| A | MET165 |
| A | ALA167 |
| A | GLY168 |
| A | LYS171 |
| A | VAL173 |
| A | THR181 |
| A | ASP183 |
| A | ARG253 |
| A | ARG259 |
| A | MET113 |
| A | HOH262 |
| A | HOH394 |
| B | GLY221 |
| A | HIS117 |
| A | ALA137 |
| A | GLY138 |
| A | PHE147 |
| A | SER149 |
| A | VAL154 |
| A | HIS155 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE S2N B 260 |
| Chain | Residue |
| A | SER220 |
| A | GLY221 |
| B | GLN68 |
| B | MET113 |
| B | HIS117 |
| B | ALA137 |
| B | GLY138 |
| B | PHE147 |
| B | SER149 |
| B | HIS155 |
| B | GLN156 |
| B | ALA167 |
| B | GLY168 |
| B | LYS171 |
| B | ARG253 |
| B | HOH309 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE S2N C 260 |
| Chain | Residue |
| C | GLN68 |
| C | HIS117 |
| C | ALA137 |
| C | GLY138 |
| C | PHE147 |
| C | SER149 |
| C | HIS155 |
| C | GLN156 |
| C | ALA167 |
| C | GLY168 |
| C | LYS171 |
| C | ASP183 |
| C | VAL190 |
| C | HIS219 |
| C | GLY221 |
| C | ARG253 |
| C | ARG259 |
| C | HOH311 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1lxa |
| Chain | Residue | Details |
| A | HIS120 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1lxa |
| Chain | Residue | Details |
| B | HIS120 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1lxa |
| Chain | Residue | Details |
| C | HIS120 |
