3I3A

Structural Basis for the Sugar Nucleotide and Acyl Chain Selectivity of Leptospira interrogans LpxA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0008610	biological_process	lipid biosynthetic process
A	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0008610	biological_process	lipid biosynthetic process
B	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
B	0009103	biological_process	lipopolysaccharide biosynthetic process
B	0009245	biological_process	lipid A biosynthetic process
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0008610	biological_process	lipid biosynthetic process
C	0008780	molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
C	0009103	biological_process	lipopolysaccharide biosynthetic process
C	0009245	biological_process	lipid A biosynthetic process
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE S2N A 260

Chain	Residue
A	GLN68
A	GLN156
A	MET165
A	ALA167
A	GLY168
A	LYS171
A	VAL173
A	THR181
A	ASP183
A	ARG253
A	ARG259
A	MET113
A	HOH262
A	HOH394
B	GLY221
A	HIS117
A	ALA137
A	GLY138
A	PHE147
A	SER149
A	VAL154
A	HIS155

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE S2N B 260

Chain	Residue
A	SER220
A	GLY221
B	GLN68
B	MET113
B	HIS117
B	ALA137
B	GLY138
B	PHE147
B	SER149
B	HIS155
B	GLN156
B	ALA167
B	GLY168
B	LYS171
B	ARG253
B	HOH309

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site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE S2N C 260

Chain	Residue
C	GLN68
C	HIS117
C	ALA137
C	GLY138
C	PHE147
C	SER149
C	HIS155
C	GLN156
C	ALA167
C	GLY168
C	LYS171
C	ASP183
C	VAL190
C	HIS219
C	GLY221
C	ARG253
C	ARG259
C	HOH311

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
A	HIS120

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
B	HIS120

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site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
C	HIS120

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