3HUC
Human p38 MAP Kinase in Complex with RL40
Summary for 3HUC
Entry DOI | 10.2210/pdb3huc/pdb |
Related | 3GCP 3GCQ 3GCS 3GCU 3GCV 3HUB |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide, ... (5 entities in total) |
Functional Keywords | dfg-out, glycine-rich loop, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42113.04 |
Authors | Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (deposition date: 2009-06-13, release date: 2010-03-09, Last modification date: 2024-02-21) |
Primary citation | Simard, J.R.,Getlik, M.,Grutter, C.,Schneider, R.,Wulfert, S.,Rauh, D. Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132:4152-4160, 2010 Cited by PubMed: 20201574DOI: 10.1021/ja908083e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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