3HUC

Human p38 MAP Kinase in Complex with RL40

3HUC の概要

• エントリーDOI: 10.2210/pdb3huc/pdb
• 関連するPDBエントリー: 3GCP 3GCQ 3GCS 3GCU 3GCV 3HUB
• 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide, ... (5 entities in total)
• 機能のキーワード: dfg-out, glycine-rich loop, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42113.04

構造登録者

Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (登録日: 2009-06-13, 公開日: 2010-03-09, 最終更新日: 2024-02-21)

• 主引用文献: Simard, J.R.,Getlik, M.,Grutter, C.,Schneider, R.,Wulfert, S.,Rauh, D.; Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.; J.Am.Chem.Soc., 132:4152-4160, 2010; PubMed: 20201574; DOI: 10.1021/ja908083e

実験手法

X-RAY DIFFRACTION (1.8 Å)