3HQR

PHD2:Mn:NOG:HIF1-alpha substrate complex

3HQR の概要

• エントリーDOI: 10.2210/pdb3hqr/pdb
• 関連するPDBエントリー: 2G1M 3HQU
• 分子名称: Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ... (5 entities in total)
• 機能のキーワード: double stranded beta-helix, alternative splicing, congenital erythrocytosis, dioxygenase, disease mutation, iron, metal-binding, oxidoreductase, vitamin c, zinc, zinc-finger, activator, cytoplasm, dna-binding, hydroxylation, isopeptide bond, nucleus, phosphoprotein, polymorphism, s-nitrosylation, transcription, transcription regulation, ubl conjugation, oxidoreductase-transcription complex, oxidoreductase/transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm : Q9GZT9 Q16665
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29667.51

構造登録者

Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (登録日: 2009-06-08, 公開日: 2009-07-28, 最終更新日: 2023-11-01)

• 主引用文献: Chowdhury, R.,McDonough, M.A.,Mecinovic, J.,Loenarz, C.,Flashman, E.,Hewitson, K.S.,Domene, C.,Schofield, C.J.; Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases; Structure, 17:981-989, 2009; PubMed: 19604478; DOI: 10.1016/j.str.2009.06.002

実験手法

X-RAY DIFFRACTION (2 Å)