3HPX

Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644)

3HPX の概要

• エントリーDOI: 10.2210/pdb3hpx/pdb
• 関連するPDBエントリー: 1SR9 3FIG 3HPS 3HPZ 3HQ1
• 分子名称: 2-isopropylmalate synthase, NICKEL (II) ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: 2-isopropylmalate synthase, leua, mycobacterium tuberculosis, truncation mutant, active site domain, tim barrel, amino-acid biosynthesis, branched-chain amino acid biosynthesis, leucine biosynthesis, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95376.16

構造登録者

Koon, N.,Squire, C.J.,Baker, E.N. (登録日: 2009-06-05, 公開日: 2010-05-19, 最終更新日: 2023-09-06)

• 主引用文献: Huisman, F.H.,Koon, N.,Bulloch, E.M.,Baker, H.M.,Baker, E.N.,Squire, C.J.,Parker, E.J.; Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding; Biochemistry, 51:2289-2297, 2012; PubMed: 22352945; DOI: 10.1021/bi201717j

実験手法

X-RAY DIFFRACTION (2.03 Å)