3HPH

Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD

3HPH の概要

• エントリーDOI: 10.2210/pdb3hph/pdb
• 関連するPDBエントリー: 1K6Y 2B4J 3F9K 3HPG
• 分子名称: Integrase, PC4 and SFRS1-interacting protein, ZINC ION, ... (6 entities in total)
• 機能のキーワード: protein-protein complex, tetramer, dna integration, endonuclease, magnesium, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, host-virus interaction, transcription, transcription regulation, zinc binding, hhcc motif, viral protein, recombination
• 由来する生物種: Maedi visna virus (MVV); 詳細
• 細胞内の位置: Nucleus: O75475
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 145232.32

構造登録者

Hare, S.,Wang, J.,Cherepanov, P. (登録日: 2009-06-04, 公開日: 2009-07-28, 最終更新日: 2023-11-01)

• 主引用文献: Hare, S.,Di Nunzio, F.,Labeja, A.,Wang, J.,Engelman, A.,Cherepanov, P.; Structural basis for functional tetramerization of lentiviral integrase; Plos Pathog., 5:e1000515-e1000515, 2009; PubMed: 19609359; DOI: 10.1371/journal.ppat.1000515

実験手法

X-RAY DIFFRACTION (2.64 Å)