3HPH
Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Integrase | polymer | 219 | 25090.5 | 4 | UniProt (P35956) Pfam (PF02022) Pfam (PF00665) In PDB | Maedi visna virus (MVV) | IN |
| 2 | E, F, G, H | PC4 and SFRS1-interacting protein | polymer | 94 | 10988.9 | 4 | UniProt (O75475) Pfam (PF11467) In PDB | Homo sapiens (human) | Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52, Dense fine speckles 70 kDa protein, DFS 70, CLL-associated antigen KW-7 |
| 3 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | A, C, D | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | B, E, H | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 6 | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 219 (UniProt: P35956)
E, F, G, H: 348 - 435 (UniProt: O75475)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Val 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 436 | - | expression tag |
| Glu 437 | - | expression tag |
| Val 438 | - | expression tag |
| Leu 439 | - | expression tag |
| Phe 440 | - | expression tag |
| Gln 441 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 144317.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 914.9 | |
| All* | Total formula weight | 145232.3 |
