3HPH
Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0015074 | biological_process | DNA integration |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0015074 | biological_process | DNA integration |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0015074 | biological_process | DNA integration |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0015074 | biological_process | DNA integration |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 220 |
| Chain | Residue |
| A | HIS12 |
| A | HIS16 |
| A | CYS40 |
| A | CYS43 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 221 |
| Chain | Residue |
| A | MET109 |
| A | MET198 |
| A | PHE201 |
| B | MET109 |
| B | PHE201 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 220 |
| Chain | Residue |
| B | HIS12 |
| B | HIS16 |
| B | CYS40 |
| B | CYS43 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 221 |
| Chain | Residue |
| B | TYR67 |
| B | THR68 |
| B | HIS69 |
| B | LYS161 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 220 |
| Chain | Residue |
| C | HIS12 |
| C | HIS16 |
| C | CYS40 |
| C | CYS43 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 221 |
| Chain | Residue |
| C | MET109 |
| C | MET198 |
| D | MET109 |
| D | PHE110 |
| D | PHE201 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 220 |
| Chain | Residue |
| D | HIS12 |
| D | HIS16 |
| D | CYS40 |
| D | CYS43 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL D 221 |
| Chain | Residue |
| D | PHE203 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 E 1 |
| Chain | Residue |
| E | HOH45 |
| E | HOH46 |
| E | LYS401 |
| E | ARG404 |
| E | TYR420 |
| E | LYS424 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 H 2 |
| Chain | Residue |
| H | HOH47 |
| H | HOH48 |
| H | LYS401 |
| H | ARG404 |
| H | TYR420 |
| H | LYS424 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00450","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00457","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 82 |
| Details | Zinc finger: {"description":"Integrase-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00450","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
