3HO5
Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex
3HO5 の概要
エントリーDOI | 10.2210/pdb3ho5/pdb |
関連するPDBエントリー | 3HO3 3HO4 |
分子名称 | Hedgehog-interacting protein, Sonic hedgehog protein, ZINC ION, ... (4 entities in total) |
機能のキーワード | receptor ectodomain, six-bladed-propeller domain, egf domain, disulfide bond, calcium cation, zinc cation, cell membrane, egf-like domain, glycoprotein, membrane, secreted, autocatalytic cleavage, developmental protein, disease mutation, holoprosencephaly, hydrolase, lipoprotein, microphthalmia, palmitate, protease, signaling protein |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Cell membrane; Peripheral membrane protein (By similarity). Isoform 2: Cytoplasm (Probable): Q96QV1 Sonic hedgehog protein C-product: Secreted, extracellular space (By similarity). Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor (By similarity): Q15465 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 127507.95 |
構造登録者 | |
主引用文献 | Bosanac, I.,Maun, H.R.,Scales, S.J.,Wen, X.,Lingel, A.,Bazan, J.F.,de Sauvage, F.J.,Hymowitz, S.G.,Lazarus, R.A. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat.Struct.Mol.Biol., 16:691-697, 2009 Cited by PubMed: 19561609DOI: 10.1038/nsmb.1632 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.01 Å) |
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