3HKY
HCV NS5B polymerase genotype 1b in complex with 1,5 benzodiazepine 6
Summary for 3HKY
Entry DOI | 10.2210/pdb3hky/pdb |
Related | 3CSO 3HKW |
Descriptor | RNA-directed RNA polymerase, (11S)-10-[(2,5-dimethyl-1,3-oxazol-4-yl)carbonyl]-11-{2-fluoro-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}-3,3-dimethyl-2,3,4,5,10,11-hexahydrothiopyrano[3,2-b][1,5]benzodiazepin-6-ol 1,1-dioxide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | hepatitis c virus, 1, 5-benzodiazepine, genotype, ns5b, polymerase, biacore, replicon, transferase |
Biological source | Hepatitis C virus subtype 1b |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972 |
Total number of polymer chains | 2 |
Total formula weight | 131637.24 |
Authors | Nyanguile, O.,De Bondt, H.L. (deposition date: 2009-05-26, release date: 2010-05-26, Last modification date: 2023-11-01) |
Primary citation | Nyanguile, O.,Devogelaere, B.,Vijgen, L.,Van den Broeck, W.,Pauwels, F.,Cummings, M.D.,De Bondt, H.L.,Vos, A.M.,Berke, J.M.,Lenz, O.,Vandercruyssen, G.,Vermeiren, K.,Mostmans, W.,Dehertogh, P.,Delouvroy, F.,Vendeville, S.,VanDyck, K.,Dockx, K.,Cleiren, E.,Raboisson, P.,Simmen, K.A.,Fanning, G.C. 1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus J.Virol., 84:2923-2934, 2010 Cited by PubMed: 20071590DOI: 10.1128/JVI.01980-09 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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