3HKY

HCV NS5B polymerase genotype 1b in complex with 1,5 benzodiazepine 6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	RNA-directed RNA polymerase	polymer	581	64817.3	2	UniProt (O92972) Pfam (PF00998) In PDB	Hepatitis C virus subtype 1b	HCV NS5B RNA POLYMERASE
2	A, B	(11S)-10-[(2,5-dimethyl-1,3-oxazol-4-yl)carbonyl]-11-{2-fluoro-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}-3,3-dimethyl-2,3,4,5,10,11-hexahydrothiopyrano[3,2-b][1,5]benzodiazepin-6-ol 1,1-dioxide	non-polymer		581.7	2	Chemie (IX6)
3	A, B	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
4	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5		water	water		18.0	672	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: O92972)

PDB	External Database	Details
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Leu 571	-	expression tag
Glu 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag
His 577	-	expression tag
His 578	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	129634.5
Non-Polymers*	Number of molecules	12
	Total formula weight	2002.7
All*	Total formula weight	131637.2

*Water molecules are not included.