3HHI

Crystal Structure of Cathepsin B from T. brucei in complex with CA074

Summary for 3HHI

Entry DOI	10.2210/pdb3hhi/pdb
Related PRD ID	PRD_001032
Descriptor	Cathepsin B-like cysteine protease, [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
Functional Keywords	cysteine protease, occluding loop, hydrolase, protease, thiol protease
Biological source	Trypanosoma brucei
Total number of polymer chains	2
Total formula weight	73318.60
Authors	Wu, P.,Kerr, I.D.,Brinen, L.S. (deposition date: 2009-05-15, release date: 2010-05-26, Last modification date: 2024-11-20)
Primary citation	Kerr, I.D.,Wu, P.,Marion-Tsukamaki, R.,Mackey, Z.B.,Brinen, L.S. Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei Plos Negl Trop Dis, 4:e701-e701, 2010 Cited by PubMed Abstract: Trypanosoma brucei is the etiological agent of Human African Trypanosomiasis, an endemic parasitic disease of sub-Saharan Africa. TbCatB and rhodesain are the sole Clan CA papain-like cysteine proteases produced by the parasite during infection of the mammalian host and are implicated in the progression of disease. Of considerable interest is the exploration of these two enzymes as targets for cysteine protease inhibitors that are effective against T. brucei. PubMed: 20544024 DOI: 10.1371/journal.pntd.0000701 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation