3HHI

Crystal Structure of Cathepsin B from T. brucei in complex with CA074

Summary for 3HHI

• Entry DOI: 10.2210/pdb3hhi/pdb
• Related PRD ID: PRD_001032
• Descriptor: Cathepsin B-like cysteine protease, [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
• Functional Keywords: cysteine protease, occluding loop, hydrolase, protease, thiol protease
• Biological source: Trypanosoma brucei
• Total number of polymer chains: 2
• Total formula weight: 73318.60

Authors

Wu, P.,Kerr, I.D.,Brinen, L.S. (deposition date: 2009-05-15, release date: 2010-05-26, Last modification date: 2023-09-06)

• Primary citation: Kerr, I.D.,Wu, P.,Marion-Tsukamaki, R.,Mackey, Z.B.,Brinen, L.S.; Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei; Plos Negl Trop Dis, 4:e701-e701, 2010; PubMed: 20544024; DOI: 10.1371/journal.pntd.0000701

Experimental method

X-RAY DIFFRACTION (1.6 Å)