3HHI
Crystal Structure of Cathepsin B from T. brucei in complex with CA074
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Cathepsin B-like cysteine protease | polymer | 325 | 35920.9 | 2 | UniProt (Q6R7Z5) Pfam (PF00112) In PDB | Trypanosoma brucei | Cysteine peptidase C (CPC) |
2 | A, B | [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE | non-polymer | 385.5 | 2 | BIRD (PRD_001032) Chemie (074) | |||
3 | A | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
4 | A, B | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
6 | B | LITHIUM ION | non-polymer | 6.9 | 1 | Chemie (LI) | |||
7 | water | water | 18.0 | 572 | Chemie (HOH) |
Sequence modifications
A, B: 23 - 340 (UniProt: Q6R7Z5)
PDB | External Database | Details |
---|---|---|
Asp 216 | Asn 216 | engineered mutation |
His 341 | - | expression tag |
His 342 | - | expression tag |
His 343 | - | expression tag |
His 344 | - | expression tag |
His 345 | - | expression tag |
His 346 | - | expression tag |
His 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 71841.7 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1476.9 | |
All* | Total formula weight | 73318.6 |