3HC5
FXR with SRC1 and GSK826
Summary for 3HC5
Entry DOI | 10.2210/pdb3hc5/pdb |
Related | 3dct 3dcu 3HC6 |
Descriptor | Bile acid receptor, Nuclear receptor coactivator 1, 3-(6-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1-benzothiophen-2-yl)benzoic acid, ... (5 entities in total) |
Functional Keywords | fxr, nuclear receptor, gw4064, alpha-helical sandwich, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, repressor, transcription, transcription regulation, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1 Nucleus : Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 30428.61 |
Authors | Williams, S.P.,Madauss, K.P. (deposition date: 2009-05-05, release date: 2009-07-21, Last modification date: 2023-09-06) |
Primary citation | Akwabi-Ameyaw, A.,Bass, J.Y.,Caldwell, R.D.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,Navas, F.,Parks, D.J.,Spearing, P.K.,Todd, D.,Williams, S.P.,Bruce Wisely, G. FXR agonist activity of conformationally constrained analogs of GW 4064. Bioorg.Med.Chem.Lett., 19:4733-4739, 2009 Cited by PubMed: 19586769DOI: 10.1016/j.bmcl.2009.06.062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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