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3HC5

FXR with SRC1 and GSK826

Summary for 3HC5
Entry DOI10.2210/pdb3hc5/pdb
Related3HC6 3dct 3dcu
DescriptorBile acid receptor, Nuclear receptor coactivator 1, 3-(6-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1-benzothiophen-2-yl)benzoic acid, ... (5 entities in total)
Functional Keywordsfxr, nuclear receptor, gw4064, alpha-helical sandwich, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, repressor, transcription, transcription regulation, zinc, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1
Nucleus : Q15788
Total number of polymer chains2
Total formula weight30428.61
Authors
Williams, S.P.,Madauss, K.P. (deposition date: 2009-05-05, release date: 2009-07-21, Last modification date: 2023-09-06)
Primary citationAkwabi-Ameyaw, A.,Bass, J.Y.,Caldwell, R.D.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,Navas, F.,Parks, D.J.,Spearing, P.K.,Todd, D.,Williams, S.P.,Bruce Wisely, G.
FXR agonist activity of conformationally constrained analogs of GW 4064.
Bioorg.Med.Chem.Lett., 19:4733-4739, 2009
Cited by
PubMed: 19586769
DOI: 10.1016/j.bmcl.2009.06.062
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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