3DCU

FXR with SRC1 and GSK8062

Summary for 3DCU

• Entry DOI: 10.2210/pdb3dcu/pdb
• Related: 3DCT
• Descriptor: Bile acid receptor, Nuclear receptor coactivator 1, 6-(4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)naphthalene-1-carboxylic acid, ... (4 entities in total)
• Functional Keywords: fxr, nuclear receptor, gw4064, alpha-helical sandwich, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, repressor, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, transcription-transcription activator complex, transcription/transcription activator
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1; Nucleus : Q15788
• Total number of polymer chains: 2
• Total formula weight: 30692.03

Authors

Williams, S.P.,Madauss, K.P. (deposition date: 2008-06-04, release date: 2008-08-12, Last modification date: 2023-08-30)

• Primary citation: Akwabi-Ameyaw, A.,Bass, J.Y.,Caldwell, R.D.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Jones, S.A.,Kaldor, I.,Liu, Y.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,III, F.N.,Parks, D.J.,Spearing, P.K.,Todd, D.,Williams, S.P.,Wisely, G.B.; Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.; Bioorg.Med.Chem.Lett., 18:4339-4343, 2008; PubMed: 18621523; DOI: 10.1016/j.bmcl.2008.06.073

Experimental method

X-RAY DIFFRACTION (2.95 Å)