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3H7W

Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS017

Summary for 3H7W
Entry DOI10.2210/pdb3h7w/pdb
Related1P97 1X0O 2A24 2B02 3H82 3f1n 3f1o 3f1p
DescriptorEndothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 2-nitro-N-(thiophen-3-ylmethyl)-4-(trifluoromethyl)aniline, ... (4 entities in total)
Functional Keywordspas domain, heterodimer, protein ligand complex., activator, angiogenesis, congenital erythrocytosis, developmental protein, differentiation, disease mutation, dna-binding, hydroxylation, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, alternative splicing, polymorphism
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus (Potential): Q99814
Nucleus: P27540
Total number of polymer chains2
Total formula weight28083.67
Authors
Key, J.M.,Scheuermann, T.H.,Anderson, P.C.,Daggett, V.,Gardner, K.H. (deposition date: 2009-04-28, release date: 2010-01-12, Last modification date: 2023-09-06)
Primary citationKey, J.,Scheuermann, T.H.,Anderson, P.C.,Daggett, V.,Gardner, K.H.
Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B
J.Am.Chem.Soc., 131:17647-17654, 2009
Cited by
PubMed: 19950993
DOI: 10.1021/ja9073062
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

217705

数据于2024-03-27公开中

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