3H7W

Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS017

3H7W の概要

• エントリーDOI: 10.2210/pdb3h7w/pdb
• 関連するPDBエントリー: 1P97 1X0O 2A24 2B02 3H82 3f1n 3f1o 3f1p
• 分子名称: Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 2-nitro-N-(thiophen-3-ylmethyl)-4-(trifluoromethyl)aniline, ... (4 entities in total)
• 機能のキーワード: pas domain, heterodimer, protein ligand complex., activator, angiogenesis, congenital erythrocytosis, developmental protein, differentiation, disease mutation, dna-binding, hydroxylation, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, alternative splicing, polymorphism
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (Potential): Q99814; Nucleus: P27540
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28083.67

構造登録者

Key, J.M.,Scheuermann, T.H.,Anderson, P.C.,Daggett, V.,Gardner, K.H. (登録日: 2009-04-28, 公開日: 2010-01-12, 最終更新日: 2023-09-06)

• 主引用文献: Key, J.,Scheuermann, T.H.,Anderson, P.C.,Daggett, V.,Gardner, K.H.; Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B; J.Am.Chem.Soc., 131:17647-17654, 2009; PubMed: 19950993; DOI: 10.1021/ja9073062

実験手法

X-RAY DIFFRACTION (1.65 Å)